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NURS6521 Week 1 Discussion: Pharmacokinetics and Pharmacodynamics

NURS6521 Week 1 Discussion: Pharmacokinetics and Pharmacodynamics NURS6521 Week 1 Discussion: Pharmacokinetics and PharmacodynamicsDiscussion: Pharmacokinetics and PharmacodynamicsAs an advanced practice nurse assisting physicians in the diagnosis and treatment of disorders, it is important to not only understand the impact of disorders on the body, but also the impact of drug treatments on the body. The relationships between drugs and the body can be described by pharmacokinetics and pharmacodynamics.Pharmacokinetics describes what the body does to the drug through absorption, distribution, metabolism, and excretion, whereas pharmacodynamics describes what the drug does to the body.When selecting drugs and determining dosages for patients, it is essential to consider individual patient factors that might impact the patient’s pharmacokinetic and pharmacodynamic processes. These patient factors include genetics, gender, ethnicity, age, behavior (i.e., diet, nutrition, smoking, alcohol, illicit drug abuse), and/or pathophysiological changes due to disease.ORDER A PLAGIARISM-FREE PAPER HEREFor this Discussion, you reflect on a case from your past clinical experiences and consider how a patient’s pharmacokinetic and pharmacodynamic processes may alter his or her response to a drug.To PrepareReview the Resources for this module and consider the principles of pharmacokinetics and pharmacodynamics.https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=1300https://www.deadiversion.usdoj.gov/drugreg/practioners/index.htmlhttps://oce.ovid.com/article/01741002-201705000-00005/HTMLReflect on your experiences, observations, and/or clinical practices from the last 5 years and think about how pharmacokinetic and pharmacodynamic factors altered his or her anticipated response to a drug.NURS6521 Week 1 Discussion: Pharmacokinetics and PharmacodynamicsConsider factors that might have influenced the patient’s pharmacokinetic and pharmacodynamic processes, such as genetics (including pharmacogenetics), gender, ethnicity, age, behavior, and/or possible pathophysiological changes due to disease.Think about a personalized plan of care based on these influencing factors and patient history in your case study.Assignment:Post a description of the patient case from your experiences, observations, and/or clinical practice from the last 5 years. Then, describe factors that might have influenced pharmacokinetic and pharmacodynamic processes of the patient you identified. Finally, explain details of the personalized plan of care that you would develop based on influencing factors and patient history in your case. Be specific and provide examples. explain details of the personalized plan of care that you would develop based on influencing factors and patient history in your case. Be specific and provide examples and also   also use 3 resources(citations) references. NURS6521 Week 1 Discussion: Pharmacokinetics and PharmacodynamicsReadingsArcangelo, V. P., & Peterson, A. M. (Eds.). (2013). Pharmacotherapeutics for advanced practice: A practical approach (3rd ed.). Ambler, PA: Lippincott Williams & Wilkins.Chapter 2, “Pharmacokinetic Basis of Therapeutics and Pharmacodynamic Principles” (pp. 15–29)This chapter examines concepts related to pharmacokinetics and pharmacodynamics. It also explores patient factors that health care providers consider when prescribing drug therapy to patients.Chapter 3, “Impact of Drug Interactions and Adverse Events on Therapeutics” (pp. 30–48)This chapter explains drug-drug, drug-food, drug-herb, and drug-disease interactions. It also reviews patient factors that influence drug interactions and then covers adverse drug reactions.Chapter 4, “Principles of Pharmacotherapy in Pediatrics” (pp. 49–59)This chapter explores concepts relating to drug selection, administration, and interaction for pediatric patients. It also compares age-related pharmacokinetic differences in children and adults.Chapter 6, “Principles of Pharmacotherapy in Elderly Patients” (pp. 66–78)This chapter describes issues and factors that affect drug therapy for elderly patients. It then explores concepts relating to drug selection, administration, and management for elderly patients.Hilmer, S. N., McLachlan, A. J., & Le Couteur, D. G. (2007). Clinical pharmacology in the geriatric patient. Fundamental & Clinical Pharmacology, 21(3), 217–230.Retrieved from the Walden Library databases.NURS6521 Week 1 Discussion: Pharmacokinetics and PharmacodynamicsThis article explores issues that health care providers consider when prescribing drug treatment to geriatric patients. It also examines the role of polypharmacy in adverse drug reactions and the importance of managing patient response to drug treatment.Scott, S. A. (2011). Personalizing medicine with clinical pharmacogenetics. Genetics in Medicine,13(12), 987–995. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290900/This article examines pharmacogenetic testing in relation to personalized drug therapy plans and explores evidence-based guidelines and recommendations on pharmacogenetic testing.Drugs.com. (2012). Retrieved August 22, 2012, from http://www.drugs.com/This website presents a comprehensive review of prescription and over-the-counter drugs including information on common uses and potential side effects. It also provides updates relating to new drugs on the market, support from health professionals, and a drug-drug interactions checker.MediaLaureate Education, Inc. (Executive Producer). (2012). Introduction to advanced pharmacology. Baltimore, MD: Author.NURS6521 Week 1 Discussion: Pharmacokinetics and PharmacodynamicsSCENARIO Patient AO has a history of obesity and has recently gained 9 pounds. The patient has been diagnosed with hypertension and hyperlipidemia. Drugs currently prescribed include the following: ● Atenolol 12.5 mg daily ● Doxazosin 8 mg daily ● Hydralazine 10 mg qid ● Sertraline 25 mg daily ● Simvastatin 80 mg daily To Prepare ● Review the Resources for this module and consider the impact of potential pharmacotherapeutics for cardiovascular disorders introduced in the media piece. ● Review the case study assigned by your Instructor for this Assignment. ● Select one the following factors: genetics, gender, ethnicity, or age factors. ● Reflect on how the factor you selected might influence the patient’s pharmacokinetic and pharmacodynamic processes. ● Consider how changes in the pharmacokinetic and pharmacodynamic processes might impact the patient’s recommended drug therapy. ● Think about how you might improve the patient’s drug therapy plan based on the pharmacokinetic and pharmacodynamic changes. Reflect on whether you would modify the current drug treatment or provide an alternative treatment option for the patient. By Day 7 of Week 2 Write a 2- to 3-page paper that addresses the following: ● Explain how the factor (genetics, gender, ethnicity, age),you selected might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study you were assigned. ● Describe how changes in the processes might impact the patient’s recommended drug therapy. Be specific and provide examples. ● Explain how you might improve the patient’s drug therapy plan and explain why you would make these recommended improvements ● Use at least 5 references. NURS6521 Week 1 Discussion: Pharmacokinetics and Pharmacodynamics

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